Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  2

Year :  2010

Pages :   407-410

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Low-Level Determination of Residual 4-Bromo Methyl-2'-Cyanobiphenyl in Valsartan by Liquid Chromatography-Mass Spectrometry



Address:   Yogeshwar Reddy M1,3*, Ramesh V2, Kista Reddy Ch3, Venugopal N1, Saravanan G1, Suresh Y1, Suryanarayana M1, Debashish Datta1 and Raju B2: 1Matrix Laboratories Ltd., R and D centre, Jinnaram Mandal, Medak, 502325, India. 2National Centre for Mass Spectrometry, Indian Institute of Chemical Technology, Hyderabad, 500 007, India. 3Department of Chemistry, P.G. College of Science, Saifabad, Hyderabad, India. *Corresponding Author
DOI No:

ABSTRACT:
A Liquid chromatographic (LC) method using mass spectrometric (MS) detection was developed and validated for the trace analysis (ppm level) of 4-Bromo methyl-2'-Cyanobiphenyl in Valsartan drug substances. LC analysis of 4-Bromo methyl-2'-Cyanobiphenyl was done on Necleosil C18 (100 mm x 4.6 mm, 3 ┬Ám) column and the mobile phase is in the ratio of 50:50:1 containing water, acetonitrile, and acetic acid. The flow rate was 1.0 mL min-1 and the elution was monitored at 225 nm. The method was validated as per International Conference on Harmonization (ICH) guidelines. LC-MS is able to quantitate up to 1.0 ppm of 4-Bromo methyl-2'-cyanobiphenyl.
KEYWORDS:
Liquid chromatography- mass spectrometry Valsartan.
Cite:
Yogeshwar Reddy M*, Ramesh V, Kista Reddy Ch, Venugopal N, Saravanan G, Suresh Y, Suryanarayana M, Debashish Datta, Raju B. Low-Level Determination of Residual 4-Bromo Methyl-2'-Cyanobiphenyl in Valsartan by Liquid Chromatography-Mass Spectrometry. Asian J. Research Chem. 3(2): April- June 2010; Page 407-410.
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