Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  2

Year :  2010

Pages :   411-415

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Insilico Prodrug Designing of Some Matrix Metallo Proteinase Inhibitors Derived From Tanomastat



Address:   Y Rajendraprasad1, M Bhagavan Raju2, KK Rajasekhar3* and S Sowjanya3
1Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam- 530003, AP, India
2CMR College of Pharmacy, Hyderabad, AP, India
3Dept. of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati -517503, AP
*Corresponding Author
DOI No:

ABSTRACT:
The present work describes the insilico prodrug designing of Tanomastat, a matrix metalloproteinase inhibitor. Tanomastat was selected as a lead and a series of prodrug-like molecules derived from it were generated. The pharmacokinetic and toxicity profile of these prodrug-like molecules was obtained by using ADME and TOX boxes web version of pharma Algorithms and ACD labs Chem Sketch software version 12.0. All prodrug-like molecules were predicted to be lipophilic, less toxic with an enhaced protein binding and better therapeutic efficacy.In conclusion, ADME and Toxicity properties of these molecules suggest advantages over Tanomastat.
KEYWORDS:
Insilico prodrug designing, Tanomastat, Matrix Metallo Proteinase Inhibitor (MMPI), Pharmacokinetic and Toxicity profile.
Cite:
Y Rajendraprasad, M Bhagavan Raju, KK Rajasekhar, S Sowjanya. Insilico Prodrug Designing of Some Matrix Metallo Proteinase Inhibitors Derived From Tanomastat. Asian J. Research Chem. 3(2): April- June 2010; Page 411-415.
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