Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  2

Year :  2010

Pages :   416-420

ISSN Print :  0974-4169

ISSN Online :  0974-4150


Registration

Allready Registrered
Click to Login

QSAR Studies of Novel 1- and 8-Substituted-3-Furfuryl Xanthines: An Adenosine Receptor Antagonist



Address:   Prarthana V Rewatkar1 and Ganesh R Kokil2*
1Dept. of Pharma. Chemistry, Bharati Vidyappeth, Poona College of Pharmacy, Erandawane, Pune, India -411038
2Dept. of Pharma. Chemistry, Sinhgad Institute of Pharmaceutical Sciences, Kusgaon(Bk.), Lonavala, India-410401
*Corresponding Author
DOI No:

ABSTRACT:
Adenosine modulates many important physiological functions, that affect the cardiovascular, renal, immune and central nervous systems. The receptors modulate the activity of adenylate cyclase either by stimulation (A2A and A2B) or inhibition (A1 and A3) of the activity. Quantitative structure activity relationship (QSAR) study for a series of 1- and 8- substituted xanthine derivatives as adenosine receptor (A2A and A2B) antagonist was performed. The QSAR models were developed using series of compounds against A2A and A2B antagonistic activity. The statistical quality of QSAR models was assessed by statistical parameters r2, r2cv (cross validated r2) and r2 pred (predictive r2).
KEYWORDS:
Furylxanthine Derivatives, Adenosine Receptor, QSAR, Multiple linear Regressions.
Cite:
Prarthana V Rewatkar, Ganesh R Kokil. QSAR Studies of Novel 1- and 8-Substituted-3-Furfuryl Xanthines: An Adenosine Receptor Antagonist. Asian J. Research Chem. 3(2): April- June 2010; Page 416-420.
[View HTML]      [View PDF]



Visitor's No. :   126875