Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  2

Year :  2010

Pages :   430-433

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and In Vitro Antibacterial Evaluations of Novel Amino-Pyrimidines

Address:   Md. Sarfraz Alam* and Garima Avasthi
Dept. of Pharmaceutical Chemistry, Babu Banarsi Das Institute of Technology and Management, Lucknow, UP
*Corresponding Author

A number of chalcones were synthesized by reacting 2-Acetyl Naphthalene, with Aryl substituted aldehydes in ethanolic NaOH, a Claisen-Schmidt condensation reaction. These chalcones were further reacted with guanidine nitrate in presence of ethanolic NaOH to obtain the amino pyrimidines. The synthesized compounds were characterized on the basis of physical ,chemical and spectroscopic data and were tested for the antibacterial activity using cup plate method. Evaluation of the compounds revealed remarkable antibacterial activity. In particular, amino-pyrimidines were found to be the most effective against Bacillus subtilis and Escherichia coli bacterial strains.
Chalcones, 2-Aminopyrimidines, Antibacterial, Guanidine nitrate.
Sarfraz Alam, Garima Avasthi . Synthesis and In Vitro Antibacterial Evaluations of Novel Amino-Pyrimidines. Asian J. Research Chem. 3(2): April- June 2010; Page 430-433.
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