Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  2

Year :  2010

Pages :   459-463

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Modifying Effects of Mosinone-A on Glycoconjugates Levels in 7, 12-Dimethyl benz(a)anthracene Induced Hamster Buccal Pouch Carcinogenesis



Address:   G Sugunadevi, K Suresh*, S Manoharan, MA Vijayaanand and K Rajalingam
Dept. of Biochemistry and Biotechnology, Faculty of Science, Annamalai University,Annamalai Nagar-608 002
*Corresponding Author
DOI No:

ABSTRACT:
The present study was designed to investigate the modifying effects of Mosinone-A on glycoconjugates (protein bound hexose, hexosamine, total sialic acid and fucose) levels in 7,12-dimethylbenz(a)anthracene (DMBA) induced hamster buccal pouch carcinogenesis 0.5% DMBA painting (three times per week) in hamster buccal pouches for 14 weeks resulted in the formation of well developed oral squamous cell carcinoma. We observed 100% tumor formation with marked abnormalities of glycoconjugates status in tumor bearing hamsters as compared to control animals. Oral administration of Mosinone-A at a dose of 2mg/kg body weight, to DMBA painted hamsters on alternate days for 14 weeks, reduced the tumor formation as well as protected the levels of cell surface glycoconjugates in DMBA painted hamsters. The present study thus suggests that Mosinone-A has potent chemopreventive efficacy as well as protected the abnormalities on cell surface glycoconjugates during DMBA induced hamster buccal pouch carcinogenesis.
KEYWORDS:
Oral cancer, DMBA, Mosinone-A, Glycoconjugates.
Cite:
G Sugunadevi, K Suresh, S Manoharan, MA Vijayaanand, K Rajalingam. Modifying Effects of Mosinone-A on Glycoconjugates Levels in 7, 12-Dimethyl benz(a)anthracene Induced Hamster Buccal Pouch Carcinogenesis. Asian J. Research Chem. 3(2): April- June 2010; Page 459-463.
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