Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  2

Year :  2010

Pages :   504-507

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Analgesic and Anti-inflammatory Activity of Some 2-Iodo-N'-[(1E)-Substituted Phenylmethylidene] Benzohydrazide Analogues



Address:   Harer Sunil L*, Rajurkar Vikas G, Kardile Nitin and Harer Priyanka S
Sharadchandra Pawar College of Pharmacy, Dumberwadi (Otur), Pune 412409. India
*Corresponding Author
DOI No:

ABSTRACT:
In the present study, eight compounds of phenylmethylidene benzohydrazide derivatives of o-iodo benzoic acid were synthesized by reacting 2-iodo benzohydrazide (1) with appropriately substituted aromatic aldehyde in glacial acetic acid yielded corresponding 2-Iodo-N'-[(1E)-Substituted Phenylmethylidene] Benzohydrazides (2). Structures of all the compounds (2) were established on the basis of elemental analysis and spectral data. These compounds were screened for analgesic activity by using Writhing test and Tail immersion method while Anti- inflammatory activity by rat paw edema method. Some of derivatives amongst them were showed significant activity against relative standards used for respective animal model.
KEYWORDS:
Phenylmethylidene benzohydrazide, o-iodo benzoic acid, Analgesic, Anti- inflammatory activity.
Cite:
Harer Sunil L, Rajurkar Vikas G, Kardile Nitin, Harer Priyanka S. Analgesic and Anti-inflammatory Activity of Some 2-Iodo-N'-[(1E)-Substituted Phenylmethylidene] Benzohydrazide Analogues. Asian J. Research Chem. 3(2): April- June 2010; Page 504-507.
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