Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  3

Year :  2010

Pages :   558-561

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Comparison of Anti-Hyperlipidemic Activity in Arjunarishta Prepared By Traditional and Modern Methods

Address:   Tiwari Preeti1* and Patel R.K.2
1Department of Pharmacognosy, Shri Sarvajanik Pharmacy College, Mehsana-384 001 (N. Gujarat)
2Department of Pharmacognosy, Shri. S. K. Patel College of Pharmaceutical Education and Research, Kherva-382711 (N. Gujarat)
*Corresponding Author

The present study was carried out to compare the lipid peroxidation activity and related hypolipidaemic activity in Arjunarishta-T and Arjunarishta -M prepared by traditional and modern methods with standard Atorvastatin. Hypolipidaemic activity was evaluated on cholesterol fed rats. The antioxidant activity of Arjunarishta-T and Arjunarishta-M was increased in a concentration dependent manner. Arjunarishta-T and Arjunarishta-M inhibited the ferrous sulphate induced lipid peroxidation in a dose dependent manner and showed Inhibitory Concentration (IC50) value 195.60 and 197.77 µg/ml, respectively. In hypolipidemic activity Arjunarishta-T and Arjunarishta-M at the dose of 2.0ml/kg body weight orally significantly reduced serum cholesterol (45% and 43%), serum LDL (61% and 58%) and serum triglycerides (35% and 34%). The increase in HDL was 17% when compared to control with both the Arjunarishta T and M and reduction in atherogenic index was found 1.393 and 1.494 in Arjunarishta-T and Arjunarishta-M treated groups respectively, which strongly supports anti-atherosclerotic property of Arjunarishta.
Arjunarishta, Lipid peroxidation, Atherogenic index, Anti-hyperlipidemic activity.
Tiwari Preeti, Patel R.K. Comparison of Anti-Hyperlipidemic Activity in Arjunarishta Prepared By Traditional and Modern Methods. Asian J. Research Chem. 3(3): July- Sept. 2010; Page 558-561.
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