Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  3

Year :  2010

Pages :   571-573

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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A Simultaneous Estimation of Perindopril and Losartan in Solid Dosage Forms by UV Spectrophotometry.



Address:   R. Vijayalakshmi, S. Archana and M.D. Dhanaraju*
Research Lab., GIET School of Pharmacy, NH-5 Chaitanya Nagar, Rajahmundry-533294
*Corresponding Author
DOI No:

ABSTRACT:
Perindopril and losartan are used in combination for treatment of hypertension. The present work deals with a simple spectrophotometric method development for simultaneous estimation of perindopril (PRL) and losartan (LSN) in two component–formulation. First order derivative spectrophotometric method is adopted to eliminate spectral interference. The method obeys beer’s law in the concentration ranges employed for evaluation. To determine the sampling wave length, 10mcg/ml of PRL and LSN were scanned from 200-350nm. The wavelengths were found to be 219 nm for PRL, where LSN showed zero crossing point and 214nm for LSN, where PRL showed zero crossing point in First order derivative spectroscopy. The recovery studies confirmed accuracy of proposed method and low values of standard deviation confirmed precision of the method. The method is validated as per ICH guidelines.
KEYWORDS:
Perindopril, Losartan, First order derivative spectroscopy.
Cite:
R. Vijayalakshmi, S. Archana, M.D. Dhanaraju. A Simultaneous Estimation of Perindopril and Losartan in Solid Dosage Forms by UV Spectrophotometry. Asian J. Research Chem. 3(3): July- Sept. 2010; Page 571-573.
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