Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  3

Year :  2010

Pages :   574-577

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Comparison of Anti-Hyperlipidemic Activity in Ashwagandharishta Prepared By Traditional and Modern Methods



Address:   Tiwari Preeti1* and Patel R.K.2
1Department of Pharmacognosy, Shri Sarvajanik Pharmacy College, Mehsana-384 001 (N. Gujarat)
2Department of Pharmacognosy, Shri. S. K. Patel College of Pharmaceutical Education and Research, Kherva-382711 (N. Gujarat)
*Corresponding Author
DOI No:

ABSTRACT:
The present study was carried out to compare the lipid peroxidation activity and related hypolipidaemic activity in Ashwagandhrishta-T and Ashwagandhrishta -M prepared by traditional and modern methods with standard Atorvastatin. Hypolipidaemic activity was evaluated on cholesterol fed rats. The antioxidant activity of Ashwagandharishta-T and Ashwagandharishta-M was increased in a concentration dependent manner. Ashwagandharishta-T and Ashwagandharishta-M inhibited the ferrous sulphate induced lipid per-oxidation in a dose dependent manner and showed inhibitory concentration (IC50) value 181.88 and 191.05 µg/ml, respectively. In hypolipidemic activity Ashwagandharishta-T and Ashwagandharishta-M at the dose of 2.0ml/kg body weight orally significantly reduced serum cholesterol (47% and 46%), serum LDL (66% and 65%), and serum triglycerides (35% and 34%). The increase in serum HDL was 19% when compared to control with both the AshwagandharishtaT and M and reduction in atherogenic index was found 1.25 and 1.29 in Ashwagandharishta-T and Ashwagandharishta-M treated groups respectively, which strongly supports anti-atherosclerotic property of Ashwagandharishta.
KEYWORDS:
Ashwagandharishta, Lipid per-oxidation, Atherogenic index, Anti-hyperlipidemic activity.
Cite:
Tiwari Preeti, Patel R.K.. Comparison of Anti-Hyperlipidemic Activity in Ashwagandharishta Prepared By Traditional and Modern Methods. Asian J. Research Chem. 3(3): July- Sept. 2010; Page 574-577..
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