Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  3

Year :  2010

Pages :   608-610

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Development and Validation of Nitazoxanide by HPTLC in Tablet Dosage Form



Address:   Sonal Bhale1* and Shyam Awate2
1Institute of Pharmaceutical Education and Research, Wardha-442301, Maharashtra, India
2Abhinav College of Pharmacy (B. Pharm), Narhe, Pune
*Corresponding Author
DOI No:

ABSTRACT:
A simple, precise, accurate, rapid and reproductive HPTLC procedure was developed for development and validation of Nitazoxanide in tablet dosage form at a single wavelength. The mobile phase used was a combination of chloroform: methanol (8:2 v/v) with 15 min time of saturation with filter paper with plate equilibrium. The detection of the combined dosage form was carried out at 330nm using 20 ×10 cm silica gel 60 f 254 TLC plate in the form of 8mm band with 14.5mm interval and migration distance allowed was 70mm. linearity was obtained in the concentration range of 5-50ug/ul of Nitazoxanide with correlation coefficients of 0.9949. The results of the analysis were validated statistically and recovery studies confirmed the accuracy of the proposed method.
KEYWORDS:
Nitazoxanide, HPTLC, Development, Validation.
Cite:
Sonal Bhale, Shyam Awate. Development and Validation of Nitazoxanide by HPTLC in Tablet Dosage Form. Asian J. Research Chem. 3(3): July- Sept. 2010; Page 608-610.
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