Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  3

Year :  2010

Pages :   608-610

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Development and Validation of Nitazoxanide by HPTLC in Tablet Dosage Form

Address:   Sonal Bhale1* and Shyam Awate2
1Institute of Pharmaceutical Education and Research, Wardha-442301, Maharashtra, India
2Abhinav College of Pharmacy (B. Pharm), Narhe, Pune
*Corresponding Author

A simple, precise, accurate, rapid and reproductive HPTLC procedure was developed for development and validation of Nitazoxanide in tablet dosage form at a single wavelength. The mobile phase used was a combination of chloroform: methanol (8:2 v/v) with 15 min time of saturation with filter paper with plate equilibrium. The detection of the combined dosage form was carried out at 330nm using 20 ×10 cm silica gel 60 f 254 TLC plate in the form of 8mm band with 14.5mm interval and migration distance allowed was 70mm. linearity was obtained in the concentration range of 5-50ug/ul of Nitazoxanide with correlation coefficients of 0.9949. The results of the analysis were validated statistically and recovery studies confirmed the accuracy of the proposed method.
Nitazoxanide, HPTLC, Development, Validation.
Sonal Bhale, Shyam Awate. Development and Validation of Nitazoxanide by HPTLC in Tablet Dosage Form. Asian J. Research Chem. 3(3): July- Sept. 2010; Page 608-610.
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