Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  3

Year :  2010

Pages :   616-619

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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New Spectrophotometric Methods for the Determination of Flutamide in Bulk and Pharmaceutical Preparations



Address:   Arvind B. Karadi1*, S. Appala Raju1, C.H. Shiva Kumar1, M. Kalpana Jyothi1, Shobha Manjunath1 and Ashok L. Ganure2
1H.K.E.S’s College of Pharmacy, Gulbarga-585 105 (KS) India
2K J College of Pharmacy, Vadasma, North Gujarat, India
*Corresponding Author
DOI No:

ABSTRACT:
Three simple and sensitive Spectrophotometric methods (A, B and C) for the quantitative estimation of Flutamide in bulk and pharmaceutical preparations have been developed. Method A is UV based on absorption of drug in Distilled water exhibiting maximum absorbance at 255nm. Method B and C are based on diazotization of Flutamide with nitrous acid followed by coupling insitu with Resorcinol and ß - Naphthol to form Yellow and Pink coloured chromogens and exhibits absorption maximum at 444.4 and 549 nm respectively. Beer’s law obeyed in the concentration range of 4-20, 2-12 and 1- 5 ?g/mL respectively for Method A, B and C. Coloured chromogens formed in above methods are stable for more than 2 hrs. The results of analysis for three methods have been validated statistically and by recovery studies.
KEYWORDS:
Flutamide, Resorcinol, β- Naphthol, UV Spectrophotometric method.
Cite:
Arvind B. Karadi, S. Appala Raju, C.H. Shiva Kumar, M. Kalpana Jyothi, Shobha Manjunath, Ashok L. Ganure. New Spectrophotometric Methods for the Determination of Flutamide in Bulk and Pharmaceutical Preparations. Asian J. Research Chem. 3(3): July- Sept. 2010; Page 616-619
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