Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  3

Year :  2010

Pages :   623-625

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Visible Spectrophotometric Determination of Ticlopidine in Pharmaceutical Formulation

Address:   M Padmalatha1, K Vanitha Prakash2*, and Eranna Dopadally3
1Vijaya College of Pharmacy, Munganoor, Hayathnagar, Hyderabad 2SSJ College of Pharmacy, V.N. Pally, Gandipet, Hyderabad
3Sultan-Ul-Uloom College of Pharmacy, Banjara Hills, Hyderabad
*Corresponding Author

Three simple, economical, precise, reliable and reproducible visible spectrophotometric methods (A, B and C) have been developed for the estimation of Ticlopidine in bulk as well as in Tablet formulation. The developed methods A, B and C are based on the formation of chloroform extractable complex of Ticlopidine with Bromocresol green (Method A), Bromophenol Blue (Method B), and Bromothymol Blue (Method C) which shows absorbance maxima at 430 nm, 449 nm and 427 nm respectively. The absorbance-concentration plot is linear over the range of 2.5-25 mcg/ml for Method A, and 2.5-20 mg/ml for Method B and 2.5-15 mcg/ml for Method C. The different experimental parameters affecting the development and stability were studied carefully and optimized. Results of analysis for all the methods were validated statistically and by recovery studies.
Ticlopidine, Bromocresol green, Bromophenol Blue, Bromothymol Blue Ultraviolet-Visible double beam spectrophotometer.
M Padmalatha, K Vanitha Prakash, Eranna Dopadally. Visible Spectrophotometric Determination of Ticlopidine in Pharmaceutical Formulation. Asian J. Research Chem. 3(3): July- Sept. 2010; Page 623-625.
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