Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  3

Year :  2010

Pages :   634-636

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Development and Validation of UV Spectrophotometric Method of Granisetron Hydrochloride in Bulk and Pharmaceutical Formulation



Address:   Prabhakar Panzade*, Prashant Puranik, Vipul Mogal and Mayur Patni
Government College of Pharmacy, Vedant Road, Osmanpura, Aurangabad-431005
*Corresponding Author
DOI No:

ABSTRACT:
A simple, accurate, cost effective and reproducible spectrophotometric method has been developed for the estimation of Granisetron hydrochloride in bulk and pharmaceutical dosage form. The developed UV spectrophotometric method is based on measurement of absorption at maximum wavelength 302.80 nm. The developed method was validated with respect to linearity, precision, accuracy and specificity, according to the ICH guidelines. Beer’s law was obeyed in the concentration range of 5-30 µg/ml having line equation y = 0.03315x + 0.01533 with correlation coefficient of 0.99981. The percentage recovery of Granisetron hydrochloride ranged from (101.6298±1.0547) in pharmaceutical dosage form. Results of the analysis were validated statistically and by recovery study.
KEYWORDS:
UV Spectroscopy, percentage recovery, Granisetron hydrochloride, ICH guidelines.
Cite:
Prabhakar Panzade, Prashant Puranik, Vipul Mogal, Mayur Patni. Development and Validation of UV Spectrophotometric Method of Granisetron Hydrochloride in Bulk and Pharmaceutical Formulation. Asian J. Research Chem. 3(3): July- Sept. 2010; Page 634-636.
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