Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  3

Year :  2010

Pages :   643-645

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Spectrophotometric Method for the Determination of Pitavastatin Calcium



Address:   B.S. Virupaxappa1*, K.H. Shivaprasad1, M.S. Latha2 and Swetha G.A.2
1Department of Chemistry PG Centre, Bellary, Gulbarga University, Gulbarga, Karnataka, India
2Department of Chemistry G M Institute of Technology, Davangere, Karnataka, India
*Corresponding Author
DOI No:

ABSTRACT:
Simple and rapid spectrophotometric method for the determination of Pitavastatin is described. The method is based on the reaction of H2O2 with Pitavastatin and its reaction with potassium iodide to liberate iodine. The liberated iodine bleaches the Blue colored Toluidine blue and is measured at 630 nm. The Beer’s law is obeyed in the range of 19.0 – 132.0 µg ml-1 for Pitavastatin using TB as reagent. The molar absorptivity, detection limit and quantization limit were also calculated. The optimum reaction conditions and other analytical parameters were evaluated. The statistical evaluation of the method is examined by determining intra- day and inter-day precision. The proposed method is simple, accurate and easy to apply for routine use.
KEYWORDS:
Spectophotometry, Pitavastatin, Toluidine Blue.
Cite:
B.S. Virupaxappa, K.H. Shivaprasad, M.S. Latha Swetha G.A.. Spectrophotometric Method for the Determination of Pitavastatin Calcium. Asian J. Research Chem. 3(3): July- Sept. 2010; Page 643-645.
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