Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  3

Year :  2010

Pages :   646-652

ISSN Print :  0974-4169

ISSN Online :  0974-4150


Allready Registrered
Click to Login

Synthesis and Biological Evaluation of Indole Fused Triazine Derivatives

Address:   Surendra Nath Pandeya1, Rajeev Kumar1*, Gopal Nath2 and Ashish Kumar Pathak1
1Department of Pharmacy, Saroj Institute of Technology and Management, Sultanpur Road, Lucknow-226002, U.P., India
2Department of Microbiology, Institute of Medical Science, Banaras Hindu University, Varanasi, U.P., India
*Corresponding Author

A series of indole fused triazine derivatives have been synthesized and characterized by elemental and spectral analysis, further the compounds have been screened for antimicrobial activity against ten strains of Gram (+) and Gram (-) bacteria. Compound 5a was found to be most active in the series against E. faecalis ATCC29212 with MIC 12.5 µg/mL. From the antimicrobial screening result, it was observed that the newly synthesized compounds 5a, 5i and 5j showed good antimicrobial activity compared with standard sulphamethoxazole.
Triazine, antibacterial activity, MIC value, indole nucleus.
Surendra Nath Pandeya, Rajeev Kumar, Gopal Nath, Ashish Kumar Pathak. Synthesis and Biological Evaluation of Indole Fused Triazine Derivatives. Asian J. Research Chem. 3(3): July- Sept. 2010; Page 646-652.
[View HTML]      [View PDF]

Visitor's No. :   320441