Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  3

Year :  2010

Pages :   646-652

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Biological Evaluation of Indole Fused Triazine Derivatives



Address:   Surendra Nath Pandeya1, Rajeev Kumar1*, Gopal Nath2 and Ashish Kumar Pathak1
1Department of Pharmacy, Saroj Institute of Technology and Management, Sultanpur Road, Lucknow-226002, U.P., India
2Department of Microbiology, Institute of Medical Science, Banaras Hindu University, Varanasi, U.P., India
*Corresponding Author
DOI No:

ABSTRACT:
A series of indole fused triazine derivatives have been synthesized and characterized by elemental and spectral analysis, further the compounds have been screened for antimicrobial activity against ten strains of Gram (+) and Gram (-) bacteria. Compound 5a was found to be most active in the series against E. faecalis ATCC29212 with MIC 12.5 µg/mL. From the antimicrobial screening result, it was observed that the newly synthesized compounds 5a, 5i and 5j showed good antimicrobial activity compared with standard sulphamethoxazole.
KEYWORDS:
Triazine, antibacterial activity, MIC value, indole nucleus.
Cite:
Surendra Nath Pandeya, Rajeev Kumar, Gopal Nath, Ashish Kumar Pathak. Synthesis and Biological Evaluation of Indole Fused Triazine Derivatives. Asian J. Research Chem. 3(3): July- Sept. 2010; Page 646-652.
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