Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  3

Year :  2010

Pages :   659-662

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis, Characterization and Biological Activities of New Pyrimidines and Pyrazoles Derivative



Address:   Vijay Kumar Tirlapur* and Kashinath Noubade
Dept. of Pharmaceutical Chemistry, Karanataka College of Pharmacy. Manhalli Road Post Box No- 53 Bidar-585403
*Corresponding Author
DOI No:

ABSTRACT:
4-aminotoluidine on diazotization followed by coupling with ethylacetoacetate gave ethyl 2-[(4-methylphenyl)diazenyl]-3-oxobutanoate (2), which on condensation with substituted benzaldehydes in basic medium gave 1-[(4-methyl phenyl)diazenyl]-4-(substituted phenyl) but-3-en-2-ones (3a-e). The compound (3a-e) on reaction with urea in presence of alkali and ethanol afforded 4-(4-substituted phenyl)-6-{[(4-methylphenyl) diazenyl] methyl}-pyrimidin-2-ol (4a-e). Treatment of compound (3a-e) with hydrazine hydrate in presence of ethanol gave 5-(4-substituted phenyl)-3-{[(4-methyl phenyl) diazenyl] methyl}-4, 5-dihydro-1H pyrazole (5a-e). All newly synthesized compounds were characterized on the basis of IR, 1HNMR and mass spectral data and evaluated for antimicrobial, analgesic activities.
KEYWORDS:
Pyrimidines, pyrazoles, antibacterial, antifungal, analgesic activity.
Cite:
Vijay Kumar Tirlapur, Kashinath Noubade. Synthesis, Characterization and Biological Activities of New Pyrimidines and Pyrazoles Derivative. Asian J. Research Chem. 3(3): July- Sept. 2010; Page 659-662.
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