Journal : Asian Journal of Research in Chemistry
Volume No. : 3
Issue No. : 3
Year : 2010
Pages : 539-541
ISSN Print : 0974-4169
ISSN Online : 0974-4150
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N. Harikrishnan*, U. Muralikrishna, P. Satya Vani, M.V. Asha Jyothi, V. Ranjithkumar and V. Haribaskar
Vels University, Dept. of Pharmaceutical Analysis, P.V. Vaithiyalingam Road, Pallavaram, Chennai.600 117
*Corresponding Author
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DOI No:
ABSTRACT:
A simple, accurate, cost effective and reproducible spectrophotometric method has been developed for the estimation of levocetirizine dihydrochloride in bulk and pharmaceutical dosage form. The UV spectrophotometric method is based on measurement of absorption at maximum wavelength 229 nm. The accuracy of the methods was assessed by recovery studies and was found to be ranging from 97.87-99.70.The developed method was validated with respect to linearity, accuracy (recovery), precision and specificity. Beers law was obeyed in the concentration range of 2-10µg/ml having line equation y = 0.026x + 0.016 with correlation coefficient of 0.999. Results of the analysis were validated statistically and by recovery study.
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KEYWORDS:
UV spectrophotometry, Levocetirizine dihydrochloride
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Cite:
N. Harikrishnan, U. Muralikrishna, P. Satya Vani, M.V. Asha Jyothi, V. Ranjithkumar, V. Haribaskar. Development and Validation of UV Spectrophotometric Method of Levocetirizine Dihydrochloride in Bulk and Pharmaceutical Formulation. Asian J. Research Chem. 3(3): July- Sept. 2010; Page 539-541.
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