Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  3

Year :  2010

Pages :   685-687

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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4-Thiazolidinones as Calcium Antagonist: Synthesis and Pharmacological Screening

Address:   Vaghela Gayatri K.1*, Patil S.B.2, Palled M.S.2 and Bhat A.R.2
1Fisher BioPharma Services (India) Pvt. Ltd, "PHARMEZ" SEZ, Plot No 22, Matoda, National Highway 8A, Ahmedabad - 382213, Gujarat, INDIA
2K.L.E.S’s College of Pharmacy, JNMC Campus, Belgaum-590 010, Karnataka
*Corresponding Author

Various derivatives of 4-thaizolidinones were synthesized by reacting Schiff bases with thioglycollic acid. These alcoholic groups were further oxidized to get the carboxylic acid derivatives. The compounds were purified using flash chromatography and were characterized by physical, chemical and elemental analysis. The compounds were screened for calcium antagonistic activity on albino rats by using Biopack data acquisition system. Some compounds showed comparable activity with standard drug Diltiazem.
4-thiazolidinones, Calcium antagonist, Calcium channel blockers, Schiff bases.
Vaghela Gayatri K., Patil S.B., Palled M.S., Bhat A.R.. 4-Thiazolidinones as Calcium Antagonist: Synthesis and Pharmacological Screening. Asian J. Research Chem. 3(3): July- Sept. 2010; Page 685-687.
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