Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  3

Year :  2010

Pages :   691-694

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Estimation of Mefenamic Acid in Its Bulk and Tablet Formulation by RP-HPLC Method



Address:   Teli M.S.*, Sawant S.S., Kumbhoje S.R., Ravetkar A.S. and Kondawar M.S.
Department of Pharmaceutical Chemistry, Appasaheb Birnale College of Pharmacy, Sangli. (M.S., India.)
*Corresponding Author
DOI No:

ABSTRACT:
Mefenamic acid is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, and antipyretic activities. A simple, rapid and specific method for analysis of mefenamic acid in bulk and tablet dosage form by a sensitive high-performance liquid chromatography is described. The mefenamic acid peak was developed on a C8 column by a mobile phase of acetonitrile: water. Mefenamic acid and internal standard (IS) diclofenac sodium were eluted at 3.133 and 2.750 min, respectively. The limit of quantitation and limit of detection of mefenamic acid in tablet was 0.9508 µg/ml and 0.3137 µg/ml at 288 nm. The method was linear over the range of 10-90 µg/ml with r2 of 0.99965.
KEYWORDS:
Mefenamic acid, High Performance Liquid Chromatography, Limit of Quantification, Limit of Detection.
Cite:
Teli M.S., Sawant S.S., Kumbhoje S.R., Ravetkar A.S., Kondawar M.S.. Estimation of Mefenamic Acid in Its Bulk and Tablet Formulation by RP-HPLC Method. Asian J. Research Chem. 3(3): July- Sept. 2010; Page 691-694.
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