Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  3

Year :  2010

Pages :   698-702

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis of 2-Imino-3-(5-Aryl-1, 3, 4-Thiadiazol-2-Yl)-5-Arylidene-1, 3-Thiazol-4-One as Potent CNS Depressant and Antimicrobial Agents



Address:   V. Murugan, Brijesh Joshi* and Geetha K.M.
Department of Pharmaceutical Chemistry and Pharmacology, Dayananda Sagar College of Pharmacy, Kumaraswamy Layout, Bangaluru – 5600078, Karnataka state
*Corresponding Author
DOI No:

ABSTRACT:
2-Imino-3-(5-aryl-1, 3, 4-thiadiazolyl)-1,3-thiazol-4-one (E) have been synthesized from Arylaldehyde and Thiosemicarbazide. Condensation of the Iminothiazol-4-one with different substituted aromatic aldehyde and fused sodium acetate in glacial acetic acid to get 2-Imino-5-(4-substituted arylidene)-3-(5-aryl-1, 3, 4-thiadiazol-2-yl) -1,3-thiazol-4-one (F1-7). The structures of the synthesized compounds were conformed on the basis of spectral data. The compounds have been screened for their possible CNS depressant and anti microbial activities. Among the synthesized compounds F1, F2, F4 and F7 showed significant CNS depressant activity and compounds F1, F2, F4 and F6 showed moderate antimicrobial activity.
KEYWORDS:
2-Imino-5-(4-substituted arylidene)-3-(5-aryl-1, 3, 4-thiadiazol-2-yl)-1, 3-thiazol-4-one; CNS depressant; Antimicrobial activity.
Cite:
V. Murugan, Brijesh Joshi, Geetha K.M.. Synthesis of 2-Imino-3-(5-Aryl-1, 3, 4-Thiadiazol-2-Yl)-5-Arylidene-1, 3-Thiazol-4-One as Potent CNS Depressant and Antimicrobial Agents. Asian J. Research Chem. 3(3): July- Sept. 2010; Page 698-702.
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