Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  3

Year :  2010

Pages :   751-754

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Microwave Assisted Synthesis, Characterization and Antimicrobial Activity of Some Schiff Bases of 2- Amino (4- Chloro Phenyl) Thiazoles



Address:   Kavitha P.N.*, S. Mohan, J. Saravanan and Subhajit Dutta
Department of Pharmaceutical Chemistry, PES College of Pharmacy, Bangalore-50, Karnataka, India
*Corresponding Author
DOI No:

ABSTRACT:
2- amino (4- chloro phenyl)thiazoles were synthesized by brominating p-chloroaceto phenone to give p-chloro phenacyl bromide which was then reacted with thiourea in microwave synthesizer to give 2- amino (4- chloro phenyl) thiazoles(II). Later the compound II were treated with ten different substituted aryl aldehydes to yield ten new Schiff bases (III). The compounds were characterized by IR, 1H NMR and Mass spectral data. Investigation on the antimicrobial activity of these compounds was determined by cup plate method against bacteria and fungi. Among the compounds tested, five compounds exhibited significant antimicrobial activity.
KEYWORDS:
Synthesis, Thiazoles, Schiff bases, Antimicrobial activity.
Cite:
Kavitha P.N., S. Mohan, J. Saravanan, Subhajit Dutta. Microwave Assisted Synthesis, Characterization and Antimicrobial Activity of Some Schiff Bases of 2- Amino (4- Chloro Phenyl) Thiazoles. Asian J. Research Chem. 3(3): July- Sept. 2010; Page 751-754.
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