Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  3

Year :  2010

Pages :   758-762

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis of Dimeric Steroids Using Cupric Chloride and 1, 3- Dibromopropane



Address:   M. Mushfiq*, Sultanat and Rakhshanda Rehman
Department of Chemistry, Aligarh Muslim University, Aligarh – 202 002 U.P. India
*Corresponding Author
DOI No:

ABSTRACT:
The dimeric steroids have been shown to exhibit such unique characteristics as detergents, medicinal, catalytic and liquid crystal properties that will lead to important applications. New dimeric steroids 1,3 (bicholest-5-enyl-3,3'-dioxy) propane (5) and 1,3 (bistigmasta-5,22-dienyl-3,3'-dioxy) propane (6) along with cholesta-4,6-diene (7) and stigmasta-4,6,22-triene (8) are synthesized by the treatment of acetic acid and CuCl2 with 1,3-dibromopropane which is proving to be a good reagent for such dimerizations. The structures (5) and (6) are supported by their physical and spectral properties (IR, 1HNMR, C13NMR and mass) and Rast’s method.
KEYWORDS:
Steroidal alkenes, dimeric steroids, 1,3-dibromopropane, cupric chloride, p-toluenesulphonylchloride.
Cite:
M. Mushfiq, Sultanat Rakhshanda Rehman. Synthesis of Dimeric Steroids Using Cupric Chloride and 1, 3- Dibromopropane. Asian J. Research Chem. 3(3): July- Sept. 2010; Page 758-762.
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