Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  3

Year :  2010

Pages :   758-762

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis of Dimeric Steroids Using Cupric Chloride and 1, 3- Dibromopropane

Address:   M. Mushfiq*, Sultanat and Rakhshanda Rehman
Department of Chemistry, Aligarh Muslim University, Aligarh – 202 002 U.P. India
*Corresponding Author

The dimeric steroids have been shown to exhibit such unique characteristics as detergents, medicinal, catalytic and liquid crystal properties that will lead to important applications. New dimeric steroids 1,3 (bicholest-5-enyl-3,3'-dioxy) propane (5) and 1,3 (bistigmasta-5,22-dienyl-3,3'-dioxy) propane (6) along with cholesta-4,6-diene (7) and stigmasta-4,6,22-triene (8) are synthesized by the treatment of acetic acid and CuCl2 with 1,3-dibromopropane which is proving to be a good reagent for such dimerizations. The structures (5) and (6) are supported by their physical and spectral properties (IR, 1HNMR, C13NMR and mass) and Rast’s method.
Steroidal alkenes, dimeric steroids, 1,3-dibromopropane, cupric chloride, p-toluenesulphonylchloride.
M. Mushfiq, Sultanat Rakhshanda Rehman. Synthesis of Dimeric Steroids Using Cupric Chloride and 1, 3- Dibromopropane. Asian J. Research Chem. 3(3): July- Sept. 2010; Page 758-762.
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