Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  3

Year :  2010

Pages :   767-771

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Spectrophotometric Methods for Simultaneous Estimation of Moxifloxacin HCl and Ketorolac Tromethamine



Address:   Pavan P. Chintawar1, Poonam N. Pawar1 and Minal T. Harde1*, Suhas V. Joshi2 and Praveen D. Chaudhari1
1Modern College of Pharmacy, Nigdi, Pune 411 044, Maharashtra, India
2Modern College of Pharmacy for Ladies, Moshi, Pune 412 105, Maharashtra, India
*Corresponding Author
DOI No:

ABSTRACT:
Three simple spectrophotometric methods have been developed for simultaneous estimation of Moxifloxacin HCl and Ketorolac Tromethamine from ophthalmic dosage form. Acidic methanol was used as solvent. Method - I involves, formation of Q- absorbance equation at 307 nm (isoabsorptive point) and 295 nm (?max of Moxifloxacin); Method - II simultaneous equation method involves the measurement of absorbance at two wavelength 295 (?max of Moxifloxacin) and 320 (?max of Ketorolac Tromethamine) and Method - III multicomponent mode of analysis involves measurement of absorbance at two wavelength 295 (?max of Moxifloxacin) and 320 (?max of Ketorolac Tromethamine); The linearity lies between 1- 14 µg/ml for Moxifloxacin and 1- 14 µg/ml for Ketorolac Tromethamine for all the three methods. The accuracy and precision of methods were determined and validated statistically. All the method showed good reproducibility and recovery with % RSD less than 1.5. All methods were found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis of Moxifloxacin HCl. and Ketorolac Tromethamine in bulk and ophthalmic dosage form.
KEYWORDS:
Moxifloxacin HCl, Ketorolac Tromethamine, Q-absorbance ratio method, Simultaneous equation method.
Cite:
Pavan P. Chintawar, Poonam N. Pawar, Minal T. Harde, Suhas V. Joshi, Praveen D. Chaudhari. Spectrophotometric Methods for Simultaneous Estimation of Moxifloxacin HCl and Ketorolac Tromethamine. Asian J. Research Chem. 3(3): July- Sept. 2010; Page 767-771.
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