Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  4

Year :  2010

Pages :   872-875

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Efficient One Pot Green Synthesis of 2-Aryl/ Heteryl- Benzothiazoles as Anti-inflammatory Agents



Address:   Dipika Vyawahare and Anna Pratima Nikalje*
Y.B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Aurangabad. 431001.MS. India
*Corresponding Author
DOI No:

ABSTRACT:
In the present investigation rapid and efficient cyclo-condensation of 2-aminothiophenol with aldehydes under microwave irradiation in solvent free conditions in presence of catalyst zirconium oxy chloride was carried out to afford the corresponding 2-substituted benzothiazoles 3a. This one pot, neat green synthesis is obtained in high purity, good yield of products and in short span of time in presence of ecofriendly catalyst under microwave irradiation. The structures of all the products are characterized by spectral analysis. All the synthesized products are screened for their anti-inflammatory activity and have shown promising anti-inflammatory activity.
KEYWORDS:
Green synthesis, ecofriendly, benzothiazole, microwave irradiation, anti-inflammatory activity.
Cite:
Dipika Vyawahare, Anna Pratima Nikalje. Efficient One Pot Green Synthesis of 2-Aryl/ Heteryl- Benzothiazoles as Anti-inflammatory Agents. Asian J. Research Chem. 3(4): Oct. - Dec. 2010; Page 872-875.
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