Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  4

Year :  2010

Pages :   885-887

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Simultaneous Estimation of Atorvastatin, Clopidogrel and Aspirin in Capsule Dosage forms using UV-Spectroscopy



Address:   Sunil Singh*, Nitin Dubey and D.K. Jain
College of Pharmacy, IPS Academy, Rajendar Nagar, Indore [Madhya Pradesh], India
*Corresponding Author
DOI No:

ABSTRACT:
Atorvastatin [R-(R*,R*)]-2-(4-fluorophenyl)-ß, d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenyl amino)carbonyl]-1H-pyrrole 1-heptanoic acid an Anti-hyperlipidemia and Clopidogrel (2-Chloro phenyl, 6-7 dihydro4H thieno [3,2-c]pyridine-5-yl)acetic acid is an Anti-platelet drug and Aspirin (2-Acetoxy benzoic acid) an NSAIDs. This paper presents two methods i.e. first derivative spectrophotometery and multicomponent spectrophotometery for simultaneous estimation of these three drugs combination in pharmaceutical formulations. The first derivative amplitudes at 276, 226 and 222 nm were utilized for simultaneous estimations. The multicomponent amplitudes at 247, 220 and 235 nm were utilizatied. Proper selection of wavelength for estimations of one drug by other in derivative spectra and multicomponent lead to successful development of methods for simultaneous estimation. The results of analysis were validated statistically that included parameters such as precision, LOD, LOQ, recovery and robustness. Both methods were simple, economical, accurate, reproducible and precise.
KEYWORDS:
Simultaneous determination; Derivative spectroscopy; Multicomponent method.
Cite:
Sunil Singh, Nitin Dubey, D.K. Jain. Simultaneous Estimation of Atorvastatin, Clopidogrel and Aspirin in Capsule Dosage forms using UV-Spectroscopy. Asian J. Research Chem. 3(4): Oct. - Dec. 2010; Page 885-887.
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