Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  4

Year :  2010

Pages :   892-894

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Determination of Metoprolol Succinate and Atorvastatin Calcium in Capsules Using RP – HPLC



Address:   T. Neelima Rani, N.K. Durga Devi*, A. Prameela Rani, B.R. Madhavi, P.S. Praveen and B.S. Mrudula
KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada-520010
*Corresponding Author
DOI No:

ABSTRACT:
A rapid sensitive and specific RP-HPLC method involving UV detection was developed and validated for the simultaneous determination and quantification of metoprolol and atorvastatin. Chromatography was carried out on a Zorbax X – C18 (150 X 4.6mm, 5 µm) column using buffer and acetonitrile (50: 50) as mobile phase at a flow rate of 1 ml/min and effluent was monitored at 280 nm. The assay was linear over 25 – 150 µg/ml for metoprolol and atorvastatin. The retention times of metoprolol and atorvastatin were found to be 5.265 and 6.856 min, respectively. The percentage recovery obtained was 100.8 and 100.61 % respectively.
KEYWORDS:
Metoprolol succinate, Atorvastatin calcium, HPLC, Combinational dosage form.
Cite:
T. Neelima Rani, N.K. Durga Devi, A. Prameela Rani, B.R. Madhavi, P.S. Praveen, B.S. Mrudula. Determination of Metoprolol Succinate and Atorvastatin Calcium in Capsules Using RP – HPLC. Asian J. Research Chem. 3(4): Oct. - Dec. 2010; Page 892-894.
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