Journal : Asian Journal of Research in Chemistry
Volume No. : 3
Issue No. : 4
Year : 2010
Pages : 895-897
ISSN Print : 0974-4169
ISSN Online : 0974-4150
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Address:
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R. Vijayalakshmi*, S. Bhargavi, S. Archana and M.D. Dhanaraju
Research Lab, GIET School of Pharmacy, NH-5, Chaitanya Nagar, Rajahmundry-533294 (India)
*Corresponding Author
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DOI No:
ABSTRACT:
Rapid, simple and sensitive spectrophotometric methods (A&B) have been developed for the determination of Atorvastatin (ATN) in pharmaceutical bulk and tablet dosage form. Method A is based on the reaction of ATN with 3-methyl-2-benzothiazolinone hydrazone and ferric chloride to form green colored chromogen. Method B is based on the formation of wine red colored chromogen with 1,2-naphthaquinone-4-sulphonate and NaOH. The absorbances of the chromogens were measured at their respective wavelengths of maximum absorbance against the corresponding reagent blank. The proposed methods have been successfully applied to the analysis of the bulk drug and its tablet dosage form. The methods have been statistically evaluated and were found to be precise and accurate.
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KEYWORDS:
Atorvastatin, 3-methyl-2-benzothiazolinone hydrazone, ferric chloride, 1, 2-naphthaquinone-4-sulphonate, sodium hydroxide.
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Cite:
R. Vijayalakshmi, S. Bhargavi, S. Archana, M.D. Dhanaraju. Spectrophotometric Determination of Atorvastatin in Pharmaceutical Formulations. Asian J. Research Chem. 3(4): Oct. - Dec. 2010; Page 895-897.
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