Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  4

Year :  2010

Pages :   903-905

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Simultaneous Spectrophotometric Estimation of Ezetimibe and Simvastatin in Bulk and Its Combined Dosage Form



Address:   K.R. Sireesha*, K. Prakash, Poluri Koteswari and K. Shanta kumari
S.N.Vanitha Pharmacy Mahavidyalaya, Hyderabad
*Corresponding Author
DOI No:

ABSTRACT:
Two simple, sensitive, accurate, precise, rapid and economical methods were developed for the estimation of Ezetimibe and Simvastatin in solid dosage form. First method is based on simultaneous equations and second method is based on absorbance ratio method. Ezetimibe has absorbance maxima at 231.2 nm and Simvastatin has Absorbance maxima at 246.2 nm in methanol. The linearity was obtained in the concentration range 2-10 µg/ml for both Ezetimibe and Simvastatin. In the first method the concentration of the drugs were determined by using simultaneous equations and in second method, concentration of the drugs were determined by using ratio of absorbance at isoabsorptive point and at ?-max of one of the drug. The proposed method was statistically validated and found that it is simple, accurate, precise and suitable for the routine analysis of pharmaceutical formulations.
KEYWORDS:
Simultaneous Equations, Absorbance Ratio, Iso-absorptive Point, validation.
Cite:
K.R. Sireesha, K. Prakash, Poluri Koteswari, K. Shanta kumari. Simultaneous Spectrophotometric Estimation of Ezetimibe and Simvastatin in Bulk and Its Combined Dosage Form. Asian J. Research Chem. 3(4): Oct. - Dec. 2010; Page 903-905.
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