Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  4

Year :  2010

Pages :   955-957

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Biological Evaluation of New Pyridine Derivatives



Address:   Yogesh Jadhav, Kushal Dawane, Vrushali Patil, A.S. Bobade, S.V. Athlekar and Abhay Chowdhary
Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Acharya Donde Marg, Parel, Mumbai-400012
*Corresponding Author
DOI No:

ABSTRACT:
The 3-Hydroxy pyridine on reaction with ethylchloro acetate in presence of K2CO3 followed by the reaction with hydrazine hydrate resulted in the formation of 3-pyridoxy acetyl hydrazide (III), which on further the reaction with CS2 and KOH cyclized to give (IV) which on reaction with different acid chloride form 2-(3-pyridoxymethyl)-5-(4-substitutedphenyl)-1,3,4-triazole. These structures are determined by the elemental analysis and spectral data (IR, 1H-NMR). These new derivatives are evaluated for in vitro antimicrobial activity against Staphylococcus aureus (ATCC 3750), Salmonella typhi (NCTC 786), Candida albicans (ATCC 10231) and Aspergillus niger (ATCC 16404).
KEYWORDS:
3-Hydroxy pyridine, 1,3,4-Oxadiazole, Anti–bacterial, Anti–fungal.
Cite:
Yogesh Jadhav, Kushal Dawane, Vrushali Patil, A.S. Bobade, S.V. Athlekar, Abhay Chowdhary. Synthesis and Biological Evaluation of New Pyridine Derivatives. Asian J. Research Chem. 3(4): Oct. - Dec. 2010; Page 955-957.
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