Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  4

Year :  2010

Pages :   958-960

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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New UV-Visible Spectrophotometric Methods for the Determination of Tadalafil in Bulk and Pharmaceutical Formulation



Address:   G.V.H. Raju*, S. Ganapathy, D.G. Sankar and P.Y. Naidu
Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003
*Corresponding Author
DOI No:

ABSTRACT:
A simple, sensitive and reproducible UV-Visible spectrophotometric methods (Method A to Method C) are developed for the determination of Tadalafil (TADL) in pure and dosage forms. Method A is based on the formation of colored species on treatment of Tadalafil (TADL) with Folin- Ciocalteu reagent in presence of 4% NaOH Solution. Method B is based on the formation of colored species on treatment of Tadalafil (TADL) with Sodium nitroprusside and Hydroxyl amine .Method C represents UV Spectrophotometric determination of Tadalafil (TADL) and its dosage forms in pH 2.9Buffer : Acetonitrile (40:60v/v) at 285nm.
KEYWORDS:
New UV-Visible Spectrophotometric Methods for the Determination of Tadalafil in Bulk and Pharmaceutical Formulation.
Cite:
G.V.H. Raju, S. Ganapathy, D.G. Sankar, P.Y. Naidu. New UV-Visible Spectrophotometric Methods for the Determination of Tadalafil in Bulk and Pharmaceutical Formulation. Asian J. Research Chem. 3(4): Oct. - Dec. 2010; Page 958-960.
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