Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  4

Year :  2010

Pages :   965-968

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Cytotoxic Activity of New Indole Derivatives

Address:   Radhika C.1, Venkatesham Akena2, Venkateshwar Rao J.1, Sarangapani M.2* 1Talla Padmavathi College of Pharmacy, Orus, Warangal-506009, A.P, India 2University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506009, A.P, India
*Corresponding Author

Some new (Napthalen-1-yloxyl/ 2-yloxy) - acetic acid (2-oxo-1, 2-dihydro-indole-3-ylidene)-hydrazides (4 and 5) have been synthesized by condensing naphthyl-1-oxy/2-oxy acetic acid hydrazides with different isatins. Their chemical structures have been confirmed by IR, NMR, and Mass spectroscopy and by elemental analysis. Investigation of cytotoxic activity was done by MTT assay method using HeLa and MCF cell lines. The compounds with 6-Bromo substitution (4e, 5e) have shown the prominent cytotoxic activity among the synthesized compounds.
Radhika C., Venkatesham Akena, Venkateshwar Rao J., Sarangapani M.. Synthesis and Cytotoxic Activity of New Indole Derivatives. Asian J. Research Chem. 3(4): Oct. - Dec. 2010; Page 965-968.
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