Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  4

Year :  2010

Pages :   986-989

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Simultaneous RP-HPLC Determination of Drotaverine Hydrochloride and Mefenamic Acid in Their Combined Tablet Dosage Form



Address:   R.S. Sakhare*, A.B. Roge, R.L. Bakal, A.D. Dewani, M.D. Kshirsagar and A.V. Chandewar
P. Wadhwani College of Pharmacy, Yavatmal-445 001 (M.S.)
*Corresponding Author
DOI No:

ABSTRACT:
A simple, precise, accurate, rapid and reproducible reverse phase high performance liquid chromatographic procedure was developed for simultaneous determination of Drotaverine HCL and Mefenamic Acid in tablet dosage form at a single wavelength. The mobile phase used was a combination of Methanol: Acetonitrile: KH2PO4 Buffer (10 mM): (40: 40: 20) pH 3.5. The detection of the combined dosage form was carried out at 240 nm and flow rate was set to 1ml/min. Linearity was obtained in the concentration range of 3 to 30 µg/ml of Drotaverine HCL and 6 to 33 µg/ml of Mefenamic Acid with correlation coefficients of 0.9998 and 0.9999, respectively. The results of the analysis were validated statistically and recovery studies confirmed the accuracy of the proposed method.
KEYWORDS:
Drotaverine HCL, Mefenamic Acid , RP-HPLC, Simultaneous estimation.
Cite:
R.S. Sakhare, A.B. Roge, R.L. Bakal, A.D. Dewani, M.D. Kshirsagar, A.V. Chandewar. Simultaneous RP-HPLC Determination of Drotaverine Hydrochloride and Mefenamic Acid in Their Combined Tablet Dosage Form. Asian J. Research Chem. 3(4): Oct. - Dec. 2010; Page 986-989.
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