Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  4

Year :  2010

Pages :   1002-1006

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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New UV-Visible Spectrophotometric Methods for the Determination of Aripiprazole in Bulk and Pharmaceutical Formulation



Address:   G.V.H. Raju*, S. Ganapathy, D.G. Sankar and P.Y. Naidu
Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003
*Corresponding Author
DOI No:

ABSTRACT:
A simple, sensitive and reproducible UV-Visible spectrophotometric methods (Method A to Method F) are developed for the determination of Aripiprazole (ARIP) in pure and dosage forms. Method A is based on the formation of colored species on treatment of Aripiprazole (ARIP) with 3-Methyl-2-benzo thiazolinone hydrazone (MBTH) and Cerric Ammonium Sulphate (CAS) .Method B is based on the formation of colored species on treatment of Aripiprazole (ARIP) with Fecl3 and 1,10 PTL. Method C is based on the formation of colored species on treatment of Aripiprazole (ARIP) with Folin- Ciocalteu reagent in presence of 4% NaOH Solution. Method D is based on the formation of colored species on treatment of Aripiprazole (ARIP) with DCQC (2,6-dichloroquinone N-chlorimide ,Gibbs Reagent). Method E is based on the formation of colored species on treatment of Aripiprazole (ARIP) with NQS (1,2-napthaquinone-4-sulphonic acid). Method F represents UV Spectrophotometric determination of Aripiprazole (ARIP) and its dosage forms in pH 3.0Buffer : Acetonitrile (62:38v/v) at 250nm.
KEYWORDS:
New UV-Visible Spectrophotometric Methods for the Determination of Aripiprazole in Bulk and Pharmaceutical Formulation.
Cite:
G.V.H. Raju, S. Ganapathy, D.G. Sankar, P.Y. Naidu. New UV-Visible Spectrophotometric Methods for the Determination of Aripiprazole in Bulk and Pharmaceutical Formulation. Asian J. Research Chem. 3(4): Oct. - Dec. 2010; Page 1002-1006.
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