Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  4

Year :  2010

Pages :   1038-1040

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Spectrophotometric determination of Nadolol in Bulk and Pharmaceutical Formulations



Address:   K. Kiranmai, V.D. Sundar, M.D. Dhanaraju and R. Vijayalakshmi*
Research Lab, GIET School of Pharmacy, NH-5 Chaitanya Nagar, Rajahmundry-533294 India
*Corresponding Author
DOI No:

ABSTRACT:
Rapid, simple and sensitive spectrophotometric method has been developed for the determination of Nadolol in pharmaceutical bulk and tablet dosage forms. Method is based on the reaction of Nadolol with Sodium Nitropruside, Hydroxyl amine and sodium carbonate, to form light green colored chromogen. The colored species has absorption maximum at 440 nm and obeys Beer’s law in the concentration range of 0.1-0.3 mg/ml. The optimum experimental parameters for the experiment have been studied. The proposed methods have been successfully applied to the analysis of the bulk drug and its tablet dosage form. Statistical analysis of the results has been carried out revealing high accuracy and good precision.
KEYWORDS:
Nadolol, Sodium Nitropruside, Hydroxyl amine HCl, Na2CO3.
Cite:
K. Kiranmai, V.D. Sundar, M.D. Dhanaraju, R. Vijayalakshmi. Spectrophotometric determination of Nadolol in Bulk and Pharmaceutical Formulations. Asian J. Research Chem. 3(4): Oct. - Dec. 2010; Page 1038-1040.
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