Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  4

Year :  2010

Pages :   1050-1053

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Simultaneous UV-Spectrophotometric Method for Estimation of Atenolol and Losartan Potassium in Tablet Dosage Form.



Address:   Rupali Kirtawade*, Pallavi Salve, Chhotaram Seervi, Kiran Patil, Anita Kulkarni and Pandurang Dhabale
Govt. College of Pharmacy, Karad- 415 124, (Satara), Maharashtra, India
*Corresponding Author
DOI No:

ABSTRACT:
Two simple, accurate, precise, reproducible and economical procedures for simultaneous estimation of Atenolol (AT) and Losartan Potassium (LP) in tablet dosage form have been developed. First method based on solving of simultaneous equation using 226 nm (?max of AT) and 208 nm (?max of LP) as two analytical wavelengths for both drugs in Methanol solvent. Second method based on an equation of area calculation of curve at two wavelength region (231 to 221 nm and 213 to 203 nm). Linearity was observed in the concentration range of 6-36 µg/ml for AT and 2-16 µg/ml for LP. The results of analysis have been validated statistically and by recovery study.
KEYWORDS:
Atenolol, Losartan Potassium, λmax, Simultaneous estimation method; Area Under Curve (AUC)
Cite:
Rupali Kirtawade, Pallavi Salve, Chhotaram Seervi, Kiran Patil, Anita Kulkarni, Pandurang Dhabale. Simultaneous UV-Spectrophotometric Method for Estimation of Atenolol and Losartan Potassium in Tablet Dosage Form. Asian J. Research Chem. 3(4): Oct. - Dec. 2010; Page 1050-1053.
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