Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  4

Year :  2010

Pages :   1065-1068

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis of Thiophene Compounds of Pharmacological Interest

Address:   Hitesh K. Barot1*, Gali Vidyasagar1, Sutariya Bhavin2 and Shah Jignesh2
1Department of Pharmaceutical Chemistry, Veerayatan Institute of Pharmacy, Jakhaniya, Bhuj-Mandvi Road, Kutch, Gujarat, India
2S.J.Thakkar Pharmacy College, Avadh Road, Rajkot, Gujarat, India
*Corresponding Author

An attempt was made to synthesize new substituted thiophenes as anti-inflammatory agent, adapting Gewald reaction. A new series of compounds were synthesized from 2-amino-N-(3-chloro-4-fluorophenyl)thiophene-3-carboxamide and the required aryl aldehydes to yield seven new Schiff bases. The structures of new compounds were established on the basis of spectral and elemental analysis. The title compound were screened for anti-inflammatory, anti-bacterial and anti-oxidant activity by serum albumin protein denaturation method, agar diffusion method and ferric ion reduction method respectively. Most of the compounds have shown promising activity.
Gewald reaction, thiophene, anti-inflammatory activity, anti-bacterial activity.
Hitesh K. Barot, Gali Vidyasagar, Sutariya Bhavin, Shah Jignesh. Synthesis of Thiophene Compounds of Pharmacological Interest. Asian J. Research Chem. 3(4): Oct. - Dec. 2010; Page 1065-1068.
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