Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  4

Year :  2010

Pages :   1099-1102

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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An improved synthesis of finasteride from 4-androsten-3,17-dione

Address:   Nguyen Hai Nam* and Ngo Anh Ngoc
Department of Pharmaceutical Chemistry and Center for New Drugs Discovery and Development (C3D), Hanoi University of Pharmacy 13-15 Le Thanh Tong, Hoan Kiem District, Hanoi, Vietnam
*Corresponding Author

An improved synthesis of 3-oxo-4-aza-5a-androst-1-ene-17ß-(N-tert-butylcarboxamide), commonly known as finasteride (1), a drug widely used for the treatment of benign prostatic hyperplasia (BPH), has been implemented via seven steps in an overall yield of 20.01% starting from 4-androsten-3,17-dione (AD). Conditions of several steps have been improved to be less expensive and more commercially viable compared to reported synthesis in literature.
Finasteride, benign prostatic hyperplasia, androst-4-en-3,17-dione, synthesis.
Nguyen Hai Nam, Ngo Anh Ngoc. An improved synthesis of finasteride from 4-androsten-3,17-dione. Asian J. Research Chem. 3(4): Oct. - Dec. 2010; Page 1099-1102.
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