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Asian Journal of Research in Chemistry
ISSN: 0974-4150(Online), 0974-4169(Print)
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Journal :
Asian Journal of Research in Chemistry
Volume No. :
3
Issue No. :
4
Year :
2010
Pages :
1099-1102
ISSN Print :
0974-4169
ISSN Online :
0974-4150
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An improved synthesis of finasteride from 4-androsten-3,17-dione
Nguyen Hai Nam
,
Ngo Anh Ngoc
nhnam@hotmail.com
Address:
Nguyen Hai Nam* and Ngo Anh Ngoc
Department of Pharmaceutical Chemistry and Center for New Drugs Discovery and Development (C3D), Hanoi University of Pharmacy 13-15 Le Thanh Tong, Hoan Kiem District, Hanoi, Vietnam
*Corresponding Author
DOI No:
ABSTRACT:
An improved synthesis of 3-oxo-4-aza-5a-androst-1-ene-17ß-(N-tert-butylcarboxamide), commonly known as finasteride (1), a drug widely used for the treatment of benign prostatic hyperplasia (BPH), has been implemented via seven steps in an overall yield of 20.01% starting from 4-androsten-3,17-dione (AD). Conditions of several steps have been improved to be less expensive and more commercially viable compared to reported synthesis in literature.
KEYWORDS:
Finasteride, benign prostatic hyperplasia, androst-4-en-3,17-dione, synthesis.
Cite:
Nguyen Hai Nam, Ngo Anh Ngoc. An improved synthesis of finasteride from 4-androsten-3,17-dione. Asian J. Research Chem. 3(4): Oct. - Dec. 2010; Page 1099-1102.
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