Journal :   Asian Journal of Research in Chemistry

Volume No. :   3

Issue No. :  4

Year :  2010

Pages :   853-858

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Antimicrobial Screening of Some Novel Cinnoline Derivatives



Address:   T.V.Yuvaraj1*, S. Hurmath Unnissa2, N.S.Surendiran3, M.Azeez Ur rahman4 and V.Binumon4
1Mother Theresa Post Graduate and Research Institute of Health Sciences, Puducherry, India-605006
2Department of Chemistry, KMCH College of Pharmacy, Coimbatore, Tamilnadu, India-641035
3Department of Biotechnology, HITS College of pharmacy, Hyderabad
4KMCH College of Pharmacy, Coimbatore, Tamilnadu, India-641035
*Corresponding Author
DOI No:

ABSTRACT:
Cinnoline is a nitrogenous organic base obtained from certain complex diazo compounds. It is an isosteric, relative to either quinoline or iso quinoline. Cinnoline itself is toxic and shows antibacterial activity against Escherichia coli. None of its derivatives have been found in nature. Its condensed bicyclic aromatic heterocycle contains two nitrogen atoms. Sulphamido group is introduced into cinnoline nucleus to get compounds with enhanced potency. Pyrazolocinnolines are obtained by diazotization of sulphanilamide followed by coupling to form corresponding hydrazones which, on intramolecular cyclisation forms 3-acetyl-6- sulphamido-cinnolin-4-ones [CN-I]. Further, treatment with hydrazine hydrate yields the expected 3’-methyl-6-sulphamido-1’substituted-pyrazolo [4, 3-C] cinnoline derivatives. The compounds were characterized by analytical techniques like TLC, UV, IR, NMR Spectral studies. Screening for antimicrobial activity against bacterial organisms like Escherichia coli, Klebsiella aurogeniosea, Micrococcus luteus, Bacillus cereus and fungal organism like Candida albicans using Disc Diffusion Method were performed.
KEYWORDS:
Cinnolines, sulphonamide, Isoniazid, UV, IR, NMR Spectroscopy and Antimicrobial screening.
Cite:
T.V. Yuvaraj, S. Hurmath Unnissa, N.S.Surendiran, M. Azeez Ur rahman, V.Binumon. Synthesis and Antimicrobial Screening of Some Novel Cinnoline Derivatives. Asian J. Research Chem. 3(4): Oct. - Dec. 2010; Page 853-858.
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