Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  1

Year :  2011

Pages :   55-57

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Antibacterial Study of Some New Schiff's Bases of 2-Hydrazinyl-1-(1H-Imidazole-1-yl)-Ethanone



Address:   Ravi N. Patel, Urviben Yashodharabhai Patel, Ripal R. Chaudhari and Dhrubo Jyoti Sen
Department of Pharmaceutical Chemistry, Shri Sarvajanik Pharmacy College, Hemchandracharya North Gujarat University, Arvind Baug, Mehsana-384001, Gujarat, India
*Corresponding Author
DOI No:

ABSTRACT:
Imidazole on reaction with chloroacetyl chloride afford 2-chloro-1-(1H-imidazole-1-yl)-ethanone, 1 which on treatment with hydrazine hydrate has yielded 2-hydrazinyl-1-(1H-imidazol-1-yl)-ethanone, 2. Condensation of 2 with various aromatic aldehydes afforded sustituted Schiff’s base of 2-hydrazinyl-1-(1H-imidazol-1-yl)-ethanone. The structures of all the products were characterized on the basis of their IR, Mass and 1H-NMR spectroscopic data analysis. All the synthesised products were screened for their antibacterial activity against gram-positive and gram-negative bacteria by cup-plate method.
KEYWORDS:
Synthesis, Imidazole, Aromatic aldehydes, Schiff’s bases, Antibacterial activity.
Cite:
Ravi N. Patel, Urviben Yashodharabhai Patel, Ripal R. Chaudhari, Dhrubo Jyoti Sen. Synthesis and Antibacterial Study of Some New Schiff's Bases of 2-Hydrazinyl-1-(1H-Imidazole-1-yl)-Ethanone. Asian J. Research Chem. 4(1): January 2011; Page 55-57.
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