Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  1

Year :  2011

Pages :   58-63

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Gold–Nanoparticles A Novel Nano-Photosensitizer for Photodynamic Therapy



Address:   Karunakaran Sulochana Meena1*, Thyagarajan Venkataraman3, Singaravel Ganesan2 and Prakasa Rao Aruna2
1Department of Chemistry, Queen Mary’s College, Chennai
2Department of Chemistry, Adhiparasakthi College of Science, Kalavai 3Department of Physics, Anna University, Chennai
*Corresponding Author
DOI No:

ABSTRACT:
Gold Nanoparticles (GNPs) of size below 5 nm were prepared by reduction of Chloroauric acid using sodium citrate and NaBH4 and characterized. High resolution transmission electron microscopic measurements revealed their size less than 5nm. Their photodynamic action was tested in human erythrocytes. The percent hemolysis showed a decrease in PDA above a particular GNPs concentration. The study of the effect of scavengers GSH and NaN3 showed formation of a considerable amount of superoxide anion and singlet oxygen that caused cell death. The detailed mechanism is discussed. GNPs being nontoxic serve as proper substitute for the conventional photosensitizers such as organic dyes.
KEYWORDS:
Photodynamic therapy; Photodynamic activity; Gold nanoparticles; Reactive oxygen species.
Cite:
Karunakaran Sulochana Meena, Thyagarajan Venkataraman, Singaravel Ganesan, Prakasa Rao Aruna. Gold–Nanoparticles A Novel Nano-Photosensitizer for Photodynamic Therapy. Asian J. Research Chem. 4(1): January 2011; Page 58-63.
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