Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  1

Year :  2011

Pages :   88-90

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Development and Validation of Method for Quantitative Estimation of Felodipine Agglomerates by High Pressure Liquid Chromatography



Address:   Ravindra J. Jarag1* and A.R. Paradkar2
1Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra India-416013
2Bharati Vidyapeeth Poona College of Pharmacy, Pune, Maharashtra India -411038
*Corresponding Author
DOI No:

ABSTRACT:
In present study, RP-HPLC method was developed for the quantitative estimation of Felodipine (calcium channel blocker used in the treatment of hypertension and angina pectoris) in agglomerates prepared by Crystallo-co-agglomeration technique. In RP-HPLC (binary gradient system consists of Jasco 2000 plus) method, felodipine was determined by isocratic system using methanol 0.055M phosphate buffer (83:17 v/v pH=3 ± 0.1) as mobile phase. Hydrochlorthaizide was adopted as an internal standard. Detection was carried out with UV detection at 232 nm. The proposed developed method is simple, sensitive, accurate, precise and rapid. The method is valid as per ICH guidelines.
KEYWORDS:
Felodipine, Crystallo-co-agglomeration (CCA) HPLC, Quantitative estimation.
Cite:
Ravindra J. Jarag, A.R. Paradkar. Development and Validation of Method for Quantitative Estimation of Felodipine Agglomerates by High Pressure Liquid Chromatography. Asian J. Research Chem. 4(1): January 2011; Page 88-90.
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