Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  1

Year :  2011

Pages :   13-23

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Foldamers are Artificial Molecular Architectures Inspired by Biopolymers which can hold the Molecules in the Matrix by Non-Covalent Interactions



Address:   Priya R. Modiya, Urviben Y. Patel, Ravi N. Patel and Dhrubo Jyoti Sen
Department of Pharmaceutical Chemistry, Shri Sarvajanik Pharmacy College, Gujarat Technological University, Arvind Baug, Mehsana-384001, Gujarat, India
*Corresponding Author
DOI No:

ABSTRACT:
Biological macromolecules are composed of one or more linear oligomers that fold into a functional form. The information that governs the final structure is encoded in the sequence of monomers and the precise functionality that they display, but accurate prediction of such structures remains a major challenge in structural biology. Recently, chemists have begun to develop small molecule systems that fold in a similar way and these may help to answer more complex questions or find applications in artificial molecular assemblies. Study of the properties of a family of oligoamides composed of alternating repeats of isophthalic acid and bisaniline building blocks have a rich supramolecular chemistry in non-polar solvents, forming macrocyclic receptors, catenanes, knots and double-stranded zipper complexes via a combination of amide‚Äďamide hydrogen bonds and aromatic interactions. Here the serendipitous discovery of a new member of the family that folds into a well-defined, compact, three-dimensional structure, governed by a combination of hydrogen bonding and aromatic interactions.
KEYWORDS:
Macromolecules, oligomers, biopolymers, folder polymers, matrix interactions.
Cite:
Priya R. Modiya, Urviben Y. Patel, Ravi N. Patel, Dhrubo Jyoti Sen. Foldamers are Artificial Molecular Architectures Inspired by Biopolymers which can hold the Molecules in the Matrix by Non-Covalent Interactions. Asian J. Research Chem. 4(1): January 2011; Page 13-23.
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