Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  1

Year :  2011

Pages :   110-113

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Antitumor Activity and Antioxidant Role of Ethanolic Extract of Pseudarthria viscida Linn against Ehrlich Ascites Carcinoma



Address:   M. Vijayabaskaran1*, G. Babu1, N. Venkateswaramurthy1, P. Sivakumar1, P. Perumal1, T. Sivakumar2, R. Sambathkumar3 and B. Jayakar4
1JKK Nataraja College of Pharmacy, Komarapalayam, Namakkal District, Tamil Nadu, INDIA-638183
2Nandha College of Pharmacy, Erode, TamilNadu, INDIA- 638 052
3Department of Pharmaceutics, Seventh of April University, Al-Zawia City, Libya
4Vinayaka Missions College of Pharmacy, Salem, TamilNadu, INDIA- 636008
*Corresponding Author
DOI No:

ABSTRACT:
The study was aimed at evaluating the antitumor and antioxidant activities of ethanol extract of Pseudarthria viscida (Family: Fabaceae) against Ehrlich ascites carcinoma (EAC)-bearing Swiss albino mice. The ethanol extract of Pseudarthria viscida (EEPV) was administered at the doses of 100 and 200 mg/kg in mice for 14 days after 24 h of tumor inoculation. The effect of EEPV on the growth of transplantable murine tumor, life span of EAC bearing mice, hematological profile and liver biochemical parameters were estimated. Treatment with EEPV decreased the tumor volume and viable cell count thereby increasing the life span of EAC bearing mice and brought back the hematological parameter more or less normal level. The effect of EEPV decreases the level of lipid peroxidation and protein content and significantly increased the level of antioxidant enzymes such as Catalase (CAT), Glutathione (GSH) and Superoxide dismutase (SOD). These observations are suggestive of the protective effect of EEPV against Ehrlich Ascites Carcinoma. (EAC).
KEYWORDS:
Pseudarthria viscida, Ehrlich ascites carcinoma, hematological parameter, antioxidant, antitumor activity.
Cite:
M. Vijayabaskaran, G. Babu, N. Venkateswaramurthy, P. Sivakumar, P. Perumal, T. Sivakumar, R. Sambathkumar, B. Jayakar. Antitumor Activity and Antioxidant Role of Ethanolic Extract of Pseudarthria viscida Linn against Ehrlich Ascites Carcinoma. Asian J. Research Chem. 4(1): January 2011; Page 110-113.
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