Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  1

Year :  2011

Pages :   116-119

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Antimicrobial Activities of Thiazolo [3, 2-a] Pyrimidine Derivatives



Address:   Monika Bansal, Ramandeep Kaur and Balbir Kaur*
Department of Chemistry, Punjabi University, Patiala-147002 (Punjab) India
*Corresponding Author
DOI No:

ABSTRACT:
In the present study a novel thiazolo [3,2-a] pyrimidines were synthesized by one pot multicomponent cyclocondensation of 2-amino-4-phenyl thiazole, benzoyl acetone and various substituted aromatic aldehydes on solid support under microwave irradiations. The 2-amino-4-phenyl thiazole was synthesized from acetophenone. Some of the compounds were screened for anti-bacterial (Staphylococcus aureus, Staphylococcus aureus (MRSA), Staphylococcus pyogenes) and antifungal (Aspergillus niger, Neurospora crassa) activities by Agar Diffusion method.
KEYWORDS:
Thiazolopyrimidines, Microwave, Silica as solid support, Antimicrobial studies.
Cite:
Monika Bansal, Ramandeep Kaur, Balbir Kaur. Synthesis and Antimicrobial Activities of Thiazolo [3, 2-a] Pyrimidine Derivatives. Asian J. Research Chem. 4(1): January 2011; Page 116-119.
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