Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  1

Year :  2011

Pages :   128-131

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Simultaneous Determination of Amlodipine Besylate and Atorvastatin Calcium in Pharmaceutical Tablet Formulation by Derivative Spectrophotometric Method



Address:   Vandana B. Patel1*, Rajnikanta Sahu2 and Bhumika M. Patel1
1Baroda College of Pharmacy, Limda, Vadodara, Gujarat, India
2Department of Pharmacy, The Maharaja Sayajirao University of Baroda, Gujarat, India
*Corresponding Author
DOI No:

ABSTRACT:
Two simple, accurate and precise methods viz. first derivative zero crossing spectrophotometry (method 1) and derivative ratio spectra zero crossing method (method 2) have been developed for simultaneous determination of amlodipine besylate and atorvastatine calcium in pure and commercial formulation without any prior separation or purification. The linearity range was found to be 5- 40 µg ml-1 for both the drugs. The value of limit of detection and limit of quantification was 0.397 µg ml-1 and 1.323 µg ml-1 for amlodipine and 0.220µg ml-1 and 0.735 µg ml-1 for atorvastatine respectively for method 1 and 0.600 µg ml-1 and 0.262 µg ml-1 for amlodipine and 0.262µg ml-1 and 0.874 µg ml-1 for atorvastatine respectively for method 2. The method was satisfactorily validated in terms of accuracy and precision. The results of the study showed that the proposed spectrophotometric methods are useful for the routine determination of amlodipine and atorvastatin in its combined pharmaceutical tablet dosage form.
KEYWORDS:
First derivative zero crossing spectrophotometry; Derivative ratio spectra zero crossing method; Amlodipine besylate; Atorvastatin calcium.
Cite:
Vandana B. Patel, Rajnikanta Sahu, Bhumika M. Patel. Simultaneous Determination of Amlodipine Besylate and Atorvastatin Calcium in Pharmaceutical Tablet Formulation by Derivative Spectrophotometric Method. Asian J. Research Chem. 4(1): January 2011; Page 128-131.
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