Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  1

Year :  2011

Pages :   147-150

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Pharmacological Screening of Some New Benzimidazole Derivatives



Address:   S. Manjula1, M. Aruna Devi2*, N. Raghunandhan3 and J. Venkateshwar Rao1
1Tallapadmavathi College of Pharmacy, Urus, Kareemabad, Warangal, A.P, India
2Trinity College of Pharmaceutical Sciences, Peddapalli, Karimnagar, A.P, India
3Balaji Institute of Pharmaceutical Sciences, Narsampet, Warangal, A.P, India
*Corresponding Author
DOI No:

ABSTRACT:
Seven different 2-[(1H-benzimidazol-2yl methyl) sulfanyl)] –N4-(phenylmethylidene) acetohydrazides were synthesized from 2-[(1H- benzimidazol-2-yl methyl) sulfanyl] acetohydrazide on reaction with different aromatic aldehydes in methanol. Each of these compounds were purified and characterized by their spectral data. All the compounds were assayed for their anti-inflammatory activity by carrageenan induced rat hind paw edema method. Some of these compounds showed moderate to considerable anti-inflammatory activity.
KEYWORDS:
Benzimidazol-2-methane thiol derivatives, aromatic aldehydes, anti-inflammatory activity.
Cite:
S. Manjula, M. Aruna Devi, N. Raghunandhan, J. Venkateshwar Rao. Synthesis and Pharmacological Screening of Some New Benzimidazole Derivatives. Asian J. Research Chem. 4(1): January 2011; Page 147-150.
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