Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  10

Year :  2011

Pages :   1557-1561

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Simultaneous Estimation of Rosuvastatin Calcium and Fenofibrate in their Combined Tablet Dosage Form by HPLC Method



Address:   T.C. Borole, M.G. Dewani, S.P. Gandhi and M.C. Damle*
Department of Quality Assurance, AISSMS College of Pharmacy, Pune - 411001, Maharashtra, India.
*Corresponding Author
DOI No:

ABSTRACT:
A Simple, fast and precise reverse phase high performance liquid chromatographic method is developed for the simultaneous determination of Rosuvastatin Calcium and Fenofibrate. Chromatography was carried out at 400C and Separation of these drugs were performed on BDS C18 column (250 x 4.6 mm, 5 µ) as stationary phase with a mobile phase comprising of Acetonitrile: water (pH adjust to 2.5 with O-Phosphoric Acid) in the ratio of 70:30 (v/v) at a flow rate of 1.5 ml/min and Detection wavelength of Rosuvastatin Calcium and Fenofibrate ware 287nm. The Retention time for Rosuvastatin Calcium and Fenofibrate were 2min and 8.5min respectively. The linearity of Rosuvastatin Calcium and Fenofibrate was in the range of 1 to 5 µg/mL. The recovery was calculated by standard addition method. The proposed method was found to be accurate, precise and rapid for simultaneous determination of Rosuvastatin Calcium and Fenofibrate. It can be used for routine analysis.
KEYWORDS:
Rosuvastatin Calcium, Fenofibrate, RP-HPLC, Validation.
Cite:
T.C. Borole, M.G. Dewani, S.P. Gandhi, M.C. Damle. Simultaneous Estimation of Rosuvastatin Calcium and Fenofibrate in their Combined Tablet Dosage Form by HPLC Method. Asian J. Research Chem. 4(10): Oct., 2011; Page 1557-1561.
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