Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  10

Year :  2011

Pages :   1562-1565

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis, Characterization and CNS Depressant Activity of Some Schiff Bases of 2-Amino-4-(4-Chlorophenyl)Thiophene-3carboxamide



Address:   Shivaji Bhattacharjee*, J. Saravanan and S. Mohan
Department of Pharmaceutical Chemistry, PES College of Pharmacy, Bangalore-50, Karnataka, India.
*Corresponding Author
DOI No:

ABSTRACT:
2-amino-4-(4-chlorophenyl)thiophene-3carboxamide was synthesized using versatile Gewald reaction conditions started with the preparation of acetamide, which was carried out by cold condensation of aniline and ethylcynoacetate, which was then reacted with p-chloro acetophenone, sulphur, diethyl amine to give 2-amino-4-(4-chlorophenyl)thiophene-3carboxamide. Later the compound was treated with twelve different substituted aryl aldehydes to yield twelve new Schiff bases (SBJ-Ia-l). The compounds were characterized by IR, 1H NMR and Mass spectral data and screened for CNS depressant activity.
KEYWORDS:
Synthesis, Thiophenes, Schiff bases, Spectral analysis, CNS depressant activity.
Cite:
Shivaji Bhattacharjee, J. Saravanan, S. Mohan. Synthesis, Characterization and CNS Depressant Activity of Some Schiff Bases of 2-Amino-4-(4-Chlorophenyl)Thiophene-3carboxamide. Asian J. Research Chem. 4(10): Oct., 2011; Page 1562-1565.
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