Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  10

Year :  2011

Pages :   1573-1577

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis And Biological Evaluation of New S-Mannich Bases of 3-Methyl-4-Phenyl-3,4,5,6,7,8, Hexahydroquinazoline-2(1h)-Thione



Address:   SenthilkumarN.*, Jayalakshmi B., Joicy Jose and SumathiK.
Department of Pharmaceutical Chemistry, JKKMMRF College of Pharmacy, B. Komarapalayam, Namakkal, Tamil Nadu – 638 183.
*Corresponding Author
DOI No:

ABSTRACT:
The chalcone was synthesized from cyclohexanone and an aromatic aldehyde by aldol condensation reaction, followed by cyclisation with thiourea results in hexahydro quinazoline. The third position is methylated by using methyl iodide, finally the mannich reaction was carried out with five different amines at second position of the hexahydro quinazoline to get five different S-Mannich bases. All the 5 synthesized new compounds were studied for their physiochemical characters. And their structures were confirmed by spectral studies (IR, NMR). These new derivatives were evaluated for analgesic and anti-inflammatory activity.
KEYWORDS:
S-Mannich Bases, Quinazoline, Chalcone.
Cite:
SenthilkumarN., Jayalakshmi B., Joicy Jose, SumathiK. Synthesis And Biological Evaluation of New S-Mannich Bases of 3-Methyl-4-Phenyl-3,4,5,6,7,8, Hexahydroquinazoline-2(1h)-Thione. Asian J. Research Chem. 4(10): Oct., 2011; Page 1573-1577.
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