Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  10

Year :  2011

Pages :   1587-1590

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Spectrophotometric Determination of Demeclocycline and Minocycline using Molybdenum (VI)



Address:   S.Kondaiah1*, M.S. Surendra Babu2*, V. Surya Narayana Rao1
1Department of Chemistry, Srikrishnadevaraya University, Anantapur-515001
2Department of Chemistry, GITAM University Hyderabad Campus, Hyderabad
*Corresponding Author
DOI No:

ABSTRACT:
The author has developed simple, new, convenient, rapid and selective methods for determination of Demeclocycline (DMC) and Minocycline (MNC). The procedure based on the observation that, DMC or MNC forms colored complexes with molybdenum (VI), the absorbance of which is proportional to the amount of tetracycline present. The variable effecting development of the color has been investigated and the conditions are optimized. Beer’s law is obeyed in the range 0.962 to 7.36 µg/ml DMC and for 0.96 to 7.68µg/ml MNC. The proposed methods can be employed for the analytical determination of molybdenum (VI). The corresponding Beer’s law ranges are 0.005 to0.040 mg/ml with DMC and 0.004 to 0.040 mg/ml with MNC. These methods are successful applied for the determination of DMC and MNC in pharmaceutical formulations. These methods are applied where ever possible for the analysis of real samples in pharmaceutical industries.
KEYWORDS:
Spectrophotometric determination, demeclocycline, minocycline, molybdenum (VI).
Cite:
S.Kondaiah, M.S. Surendra Babu, V. Surya Narayana Rao. Spectrophotometric Determination of Demeclocycline and Minocycline using Molybdenum (VI). Asian J. Research Chem. 4(10): Oct., 2011; Page1587-1590.
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